Potassium Channels in Epilepsy
نویسندگان
چکیده
منابع مشابه
Idiopathic epilepsy of childhood and potassium ion channels.
The etiology of common idiopathic epileptic syndromes is genetically determined, but the complex pattern of inheritance suggests an epistatic interaction of several susceptibility genes. Mutations in over 70 genes now define biological pathways leading to rare monogenic forms of epilepsy in humans and animals. Recognizing the molecular basis of an ion-channel disease has provided new opportunit...
متن کاملReview Idiopathic epilepsy of childhood and potassium ion channels
The etiology of common idiopathic epileptic syndromes is genetically determined, but the complex pattern of inheritance suggests an epistatic interaction of several susceptibility genes. Mutations in over 70 genes now define biological pathways leading to rare monogenic forms of epilepsy in humans and animals. Recognizing the molecular basis of an ion-channel disease has provided new opportunit...
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Introduction: We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. Methods: We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior te...
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The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
متن کاملIon channels in epilepsy.
Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation to neurotransmitter release. These mechanisms are tightly regulated to create a balance between excitation and inhibition...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2016
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a022871